drugset / Trial / NCT01922141
Aliskiren Study of Safety and Efficacy in Senior Hypertensives
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study is designed to compare the blood pressure lowering efficacy of aliskiren, a combination of aliskiren plus amlodipine, and ramipril in elderly patients with mild to moderate hypertension. It will also compare the long-term safety of an aliskiren-based regimen to a ramipril-based regimen
Timeline
- Start
- 2015-05
- Primary completion
- 2018-06
- Completion
- 2018-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aliskiren | Small molecule | 150 mg | — |
| Subject | Aliskiren | Small molecule | 300 mg | — |
| Subject | Amlodipine | Other / unclassified | 5 mg | — |
| Subject | Amlodipine | Other / unclassified | 10 mg | — |
| Comparator | Ramipril | Small molecule | 5 mg | — |
| Comparator | Ramipril | Small molecule | 10 mg | — |
| Background | Hydrochlorothiazide | Unknown | 12.5 mg | — |
| Background | Hydrochlorothiazide | Unknown | 25 mg | — |