drugset / Trial / NCT01924299
A Study of Baricitinib When Administered With Ketoconazole or Fluconazole in Healthy Participants
Non-randomizedParallel-groupOpen-labelBasic science
Summary
The main purpose of this study is to look at the effect of ketoconazole and fluconazole on how much baricitinib gets into the blood stream. The study will also look at the tolerability of baricitinib and ketoconazole when given together and the tolerability of baricitinib and fluconazole when given together. Participants will be recruited into 1 of 2 treatment groups (Group A or Group B). Each treatment group will participate in 2 study periods. Participants will take baricitinib alone in 1 period and baricitinib with either ketoconazole or fluconazole in the other period. This study will last approximately 7 weeks.
Timeline
- Start
- 2013-08
- Primary completion
- 2013-11
- Completion
- 2013-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Baricitinib | Small molecule | 10 mg | Oral |
| Subject | Fluconazole | Small molecule | 200 mg | Oral |
| Subject | Ketoconazole | Small molecule | 400 mg | Oral |
Indications
No indication recorded.