drugset / Trial / NCT01944293

Ketamine for Suicidality in Bipolar Depression

NCT01944293

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study is designed to compare the effectiveness of two medications, Ketamine and Midazolam, for rapidly relieving suicidal thoughts in people suffering from bipolar depression. The first drug, ketamine, is an experimental antidepressant that early studies have shown may quickly reduce suicidal thoughts, but we are not sure how well it may work. Midazolam, the comparison drug, is not thought to reduce depression or suicidal thoughts.

Timeline

Start
2013-09
Primary completion
2017-09
Completion
2018-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Ketamine Small molecule 0.5 mg/kg Intravenous
Comparator Midazolam Small molecule 0.02 mg/kg Intravenous