Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine

Summary

The purpose of the current study is to evaluate the efficacy of d-cycloserine in augmenting treatment of smoking cessation for individuals with panic attacks. The investigators hypothesize that individuals receiving DCS (versus those receiving placebo) will evidence greater smoking abstinence rates and decreased panic symptoms after receiving a combined CBT-based treatment for smokers with panic attacks.

Timeline

Start

2013-10

Primary completion

2018-10

Completion

2018-10

Outcome

Missed primary endpoint

registry analysis (superiority test); PSRT_DCS vs PSRT_PBO; Logit difference (final values) 0.64 (95% CI -2.25 to 0.97); two-phase growth curve model; note: p=ns 2-sided NCT01944423 ↗

Publications

• Smits JAJ, Zvolensky MJ, Otto MW, Piper ME, Baird SO, Kauffman BY, Lee-Furman E, Alavi N, Dutcher CD, Papini S, Rosenfield B, Rosenfield D. Enhancing panic and smoking reduction treatment with D-Cycloserine: A pilot randomized clinical trial. Drug Alcohol Depend. 2020 Mar 1;208:107877. doi: 10.1016/j.drugalcdep.2020.107877. Epub 2020 Jan 22.

Drugs

Indications