drugset / Trial / NCT01949233
The Oxford Marfan Trial
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The primary objective of the trial is to estimate the effects of allocation to irbesartan, or doxycycline, or a combination of both irbesartan and doxycycline, compared with placebo, on measures of elastic function of the aorta in people with the Marfan syndrome and enlargement of the aorta.
Timeline
- Start
- 2013-10
- Primary completion
- 2015-10
- Completion
- 2017-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Doxycycline | Small molecule | 100 mg | — |
| Subject | Doxycycline | Small molecule | 200 mg | — |
| Subject | Irbesartan | Small molecule | 150 mg | — |
| Subject | Irbesartan | Small molecule | 300 mg | — |