drugset / Trial / NCT01952769

Anti PD1 Antibody in Diffuse Intrinsic Pontine Glioma

NCT01952769

Phase 1/2 Unknown 50 enrolled Hadassah Medical Organization
NaSingle-groupOpen-labelTreatment

Summary

Diffuse pontine gliomas are incurable with currently used treatments. based on data stating that progressive tumors inhibit immune system, would try to enhance immune system activity and tumor cell killing. anti PD1 prevents one of the important mechanisms allowing the tumor to supress the immune system thus we hope it will allow for prolonged control of the tumors

Timeline

Start
2014-02
Primary completion
2018-11
Completion
2019-04

Drugs

EvaluationDrugModalityDoseRoute
Subject Pidilizumab Monoclonal antibody 1 mg/kg Intravenous
Subject Pidilizumab Monoclonal antibody 6 mg/kg Intravenous