drugset / Trial / NCT01957956

Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

NCT01957956

Phase 0 Completed 21 enrolled Mayo Clinic
NaSingle-groupOpen-labelTreatment

Summary

This pilot clinical trial studies vaccine therapy and temozolomide in treating patients with newly diagnosed glioblastoma. Vaccines made from a person's white blood cells mixed with tumor proteins may help the body build an effective immune response to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving vaccine therapy and temozolomide may be an effective treatment for glioblastoma.

Timeline

Start
2013-11-11
Primary completion
2016-11-16
Completion
2016-11-16

Drugs

EvaluationDrugModalityDoseRoute
Subject Malignant Glioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine Vaccine Intramuscular
Subject Temozolomide Small molecule Oral