Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil

Summary

This is an 8-week, randomized, placebo-controlled trial of modafinil in stable bipolar disorder patients. Results will provide information on a promising treatment for simultaneously treating both sleep and cognitive problems in stable bipolar patients. These disabling symptoms persist despite stable mood and are strongly associated with functional disability, making them important treatment targets that have not yet been adequately addressed.

Timeline

Start

2014-01

Primary completion

2017-11-09

Completion

2017-11-09

Publications

• Lipschitz JM, Perez-Rodriguez M, Majd M, Larsen E, Locascio J, Pike CK, Shanahan M, Burdick KE. Modafinil's effects on cognition and sleep quality in affectively-stable patients with bipolar disorder: a pilot study. Front Psychiatry. 2023 Sep 4;14:1246149. doi: 10.3389/fpsyt.2023.1246149. eCollection 2023.

Drugs

Indications