Seizure Prophylaxis in Aneurysm Repair

Summary

Seizures are a potential complication of surgical repair of intracranial aneurysms. In order to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during the intra-operative and post-operative period, however, such practice is not supported by clinical data. Retrospective review found the incidence of postoperative seizures was higher in those who received anti-epileptics versus those who did not. The goal is to examine the utility of levetiracetam (Keppra) for seizure prophylaxis in patients undergoing surgical repair of unruptured intracranial aneurysms.

Timeline

Start

2013-07

Primary completion

2016-02

Completion

2016-02

Outcome

Outcome not reported

Stopped (Enrollment): “Lack of enrollment - since the start of the study in 2013, only 17 subjects have consented. Of those, only 8 completed the study.”

Drugs

Indications