Study of Icariin for Bipolar Disorder and Co-Occurring Substance Use Disorders
Summary
This study is being done to see if icariin will help with depression in patients with bipolar disorder and alcohol or cocaine use disorders. The pills used in this study contain 20% icariin.
Timeline
- Start
- 2013-10
- Primary completion
- 2015-06
- Completion
- 2015-06
Outcome
Mixed primary results
registry MEAN Baseline: 17.5 (Standard Deviation 5.2) HAMD scale units NCT01979133 ↗
registry MEAN Week 8: 9 (Standard Deviation 7.4) HAMD scale units NCT01979133 ↗
registry 2. 0 - no depression; 52 - very severe depression (lower score corresponds to a better outcome). NCT01979133 ↗
registry analysis (superiority or other test); Baseline vs Week 8; p = .012; Wilcoxon (Mann-Whitney) NCT01979133 ↗
registry MEAN Baseline: 4.1 (Standard Deviation 2.4) Days Per Week NCT01979133 ↗
registry MEAN Week 8: 3.3 (Standard Deviation 1.0) Days Per Week NCT01979133 ↗
registry analysis (superiority or other test); Baseline vs Week 8; p = .231; Wilcoxon (Mann-Whitney) NCT01979133 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Icariin | Traditional medicine (herbal / TCM) | 100 mg | — |
| Subject | Icariin | Traditional medicine (herbal / TCM) | 200 mg | — |
| Subject | Icariin | Traditional medicine (herbal / TCM) | 300 mg | — |