D-Cycloserine Augmentation of Cognitive Behavioral Therapy for Delusions

Summary

This study is a placebo-controlled 12 week trial of DCS augmentation of once-weekly CBT sessions in 60 schizophrenia subjects with antipsychotic-resistant delusions. In addition to testing efficacy, this trial will characterize DCS effects in terms of time course and persistence of response and will examine DCS effects on memory consolidation and cognitive flexibility as possible mediators of DCS enhancement of CBT for delusions.

Timeline

Start

2014-02

Primary completion

2017-05

Completion

2017-10

Drugs

Indications