drugset / Trial / NCT01984229
A Study of the Effects of Posaconazole on Alectinib (RO5424802) Pharmacokinetics in Healthy Volunteers
Non-randomizedCrossoverOpen-labelTreatment
Summary
This open-label study will investigate whether multiple oral doses of posaconazole affect the single dose pharmacokinetics of alectinib in healthy volunteers.
Timeline
- Start
- 2013-12
- Primary completion
- 2014-03
- Completion
- 2014-03
Outcome
Met primary endpoint
registry Geometric Least Square Mean Ratio 118 (90% CI 102 to 137) NCT01984229 ↗
registry Geometric Least Square Mean Ratio 177 (90% CI 159 to 198) NCT01984229 ↗
registry Geometric Least Square Mean Ratio 175 (90% CI 157 to 195) NCT01984229 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Alectinib | Small molecule | 40 mg | Oral |
| Subject | Posaconazole | Small molecule | 400 mg | Oral |
Indications
No indication recorded.