Correlate BRCA1 Protein Expression With Response to DNA Damaging Chemotherapy

Summary

Primary Objective: To evaluate if low BRCA1 protein expression has a preferential effect on response when metastatic breast cancer patients are treated with DNA damaging chemotherapy agent, compared to historical controls Secondary Objective: To evaluate if low BRCA1 protein expression has a preferential effect on tumor progression when metastatic breast cancer patients are treated with DNA damaging chemotherapy agent, compared to historical controls

Timeline

Start

2013-11-05

Primary completion

2022-12-31

Completion

2022-12-31

Outcome

Outcome not reported

Stopped (Enrollment): “The PI determined that study specimens being obtained did not yield sufficient data to analyze the prespecified outcome measures and decided to terminate the study prior to meeting enrollment goals.”

Drugs

Indications