The Effects of Midazolam on the Quality of Postoperative Recovery

NCT01993459 ↗

Phase 4 Completed 192 enrolled Erasmus Medical Center

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to determine whether Midazolam given pre-operatively to patients undergoing abdominal surgery improves the quality of recovery.

Timeline

Start: 2014-02
Primary completion: 2015-10
Completion: 2015-10

Outcome

Missed primary endpoint

paper not significantly different in the midazolam group compared with controls [166.4 (17.0) vs 163.9 (19.8), respectively; mean difference, 2.3; PMID 31576513 ↗

paper 95% confidence interval, - 2.9 to 8.4; P = 0.35 PMID 31576513 ↗

Publications

van Beek S, Kroon J, Rijs K, Mijderwijk HJ, Klimek M, Stolker RJ. The effect of midazolam as premedication on the quality of postoperative recovery after laparotomy: a randomized clinical trial. Can J Anaesth. 2020 Jan;67(1):32-41. doi: 10.1007/s12630-019-01494-6. Epub 2019 Oct 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Midazolam	Small molecule	3 mg	Intravenous