Parasite Clearance Time and Time to Recurrent Infection Following Treatment With Artemether/Lumefantrine

NCT01998295 ↗

Phase 4 Completed 45 enrolled Muhimbili University of Health and Allied Sciences Karolinska Institutet · collab

NaSingle-groupOpen-labelTreatment

Summary

Plasmodium falciparum resistance against artemisinins has been confirmed in South-East Asia and it is expressed phenotypically as a slow rate of parasite clearance. Nonetheless, it is not known whether the problem exist in Tanzania. This study assessed parasite clearance time and time to recurrent infection following treatment with Artemether/Lumefantrine (AL) among children with uncomplicated malaria.

Timeline

Start: 2012-05
Primary completion: 2012-06
Completion: 2012-07

Publications

Mwaiswelo R, Ngasala B, Jovel I, Xu W, Larsson E, Malmberg M, Gil JP, Premji Z, Mmbando BP, Martensson A. Prevalence of and Risk Factors Associated with Polymerase Chain Reaction-Determined Plasmodium falciparum Positivity on Day 3 after Initiation of Artemether-Lumefantrine Treatment for Uncomplicated Malaria in Bagamoyo District, Tanzania. Am J Trop Med Hyg. 2019 May;100(5):1179-1186. doi: 10.4269/ajtmh.18-0729.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Artemether	Small molecule	—	—
Comparator	lumefantrine	Small molecule	—	—

Indications

No indication recorded.