Tofacitinib Ointment For Atopic Dermatitis (Atopic Eczema)

Summary

The study is being conducted to evaluate the efficacy, safety and tolerability of 2% tofacitinib ointment (20 mg/g) BID (twice daily) in subjects with mild to moderate atopic dermatitis compared to placebo (vehicle) BID for 4 weeks.

Timeline

Start

2013-12

Primary completion

2014-09

Completion

2014-09

Outcome

Met primary endpoint

registry Tofacitinib 20 mg/g BID vs Vehicle BID; p <0.0001; Mean Difference (Final Values) -51.8 (80% CI -62.8 to -40.8); Mixed Models Analysis NCT02001181 ↗

Publications

• Purohit VS, Ports WC, Wang C, Riley S. Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning. J Clin Pharmacol. 2019 Jun;59(6):811-820. doi: 10.1002/jcph.1360. Epub 2018 Dec 17.

Drugs

Indications