Arginase Inhibition in Ischemia-reperfusion Injury

Summary

The present project is designed to test the hypothesis that arginase contributes to endothelial dysfunction induced by ischemia-reperfusion in patients with coronary artery disease.

Timeline

Start

2012-01

Primary completion

2013-04

Completion

2013-09

Publications

• Kovamees O, Shemyakin A, Pernow J. Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus. PLoS One. 2014 Jul 29;9(7):e103260. doi: 10.1371/journal.pone.0103260. eCollection 2014.

Drugs

Indications