Role Of Phosphorus And FGF 23 In Patients With Dent Disease

Summary

Patients with Dent disease have suppressed levels of FGF 23 which contributes to hypercalciuria, kidney stones, nephrocalcinosis and renal failure. Supplementation with phosphorus may reduce hypercalciuria.

Timeline

Start

2014-09

Primary completion

2019-01

Completion

2019-01

Publications

• Reynolds CJ, Haskic Z, Seide BM, Romero MF, Goldfarb DS, Lieske JC, Beara-Lasic L. The Significance of Fibroblast Growth Factor 23 and 24,25-Dihydroxyvitamin D in Dent Disease Type 1. Clin J Am Soc Nephrol. 2026 Feb 27;21(5):811-21. doi: 10.2215/CJN.0000000978. Online ahead of print.

Drugs

Indications