drugset / Trial / NCT02023554
Drug Interaction Study of Azithromycin and Theophylline
Non-randomizedSingle-groupOpen-labelBasic science
Summary
Macrolides are potent inhibitors of cytochrome P450 isoenzyme 3A4（CYP3A4）and thus interfere with the pharmacokinetics of many other drugs that are metabolised by this enzyme like theophylline.The aim of this study is to determine whether azithromycin can effect theophylline metabolism in patients.
Timeline
- Start
- 2013-12
- Primary completion
- 2014-07
- Completion
- 2014-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Azithromycin | Small molecule | 500 mg | Oral |
| Subject | Theophylline | Small molecule | 100 mg | Oral |