Naltrexone for Individuals of East Asian Descent

NCT02026011 ↗

Phase 2 Completed 87 enrolled University of California, Los Angeles National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collab

RandomizedCrossoverTriple-blindTreatment

Summary

This study will elucidate the pharmacogenetic effects of the Asn40Asp SNP of the OPRM1 gene on biobehavioral and neural markers of response to naltrexone in individuals of East Asian descent, an ethnic group most likely to express the positive predictive allele.

Timeline

Start: 2013-12
Primary completion: 2016-09
Completion: 2016-09

Publications

Background Ray LA, Bujarski S, Chin PF, Miotto K. Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study. Neuropsychopharmacology. 2012 Jan;37(2):445-55. doi: 10.1038/npp.2011.192. Epub 2011 Sep 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Naltrexone	Small molecule	50 mg	—

Naltrexone for Individuals of East Asian Descent

Summary

Timeline

Publications

Drugs

Indications