Controlled Trial of Chinese Herbal Medicine to Treat Allergic Rhinitis
Summary
The aim of this study is to test and compare the effectiveness between three groups - Cure-Allergic Rhinitis Syrup (CS), Yuk ping fung San (YS) and placebo groups - of adolescents (nursing students) with Allergic Rhinitis (AR) in improving their symptoms of AR, body constitution pattern and health-related quality of life. • The hypothesis are to test the effectiveness of the CS treatment on these students' AR symptoms and quality of life at immediately, one month and two months after completion of the 4-week intervention, when compared with the YS treatment and placebo group. 1. Cure-Allergic Rhinitis Syrup (CS) group will show significantly reduction of AR symptoms over the 2-month follow-up, when compared to those in YS and placebo groups. 2. CS group will indicate a healthier body constitution pattern over the follow-up, when compared to those with YS and placebo group. 3. CS group will indicate significantly greater improvement of their quality of life over 2-month follow-up, when compared to those with YS and placebo group.
Timeline
- Start
- 2012-06
- Primary completion
- 2014-08
- Completion
- 2014-10
Outcome
Met primary endpoint
paper The results of Generalised Estimating Equations test followed by pairwise contrasts tests indicated that the participants who received CS showed significantly greater reduction of symptoms PMID 24986270 ↗
paper improvements in quality of life (mean difference of CS vs. placebo=12.81-16.76, P<0.001) PMID 24986270 ↗
Publications
- Background Jung JW, Kang HR, Ji GE, Park MS, Song WJ, Kim MH, Kwon JW, Kim TW, Park HW, Cho SH, Min KU. Therapeutic effects of fermented red ginseng in allergic rhinitis: a randomized, double-blind, placebo-controlled study. Allergy Asthma Immunol Res. 2011 Apr;3(2):103-10. doi: 10.4168/aair.2011.3.2.103. Epub 2011 Feb 14.
- Background Yang SH, Yu CL, Chen YL, Chiao SL, Chen ML. Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects. Int Immunopharmacol. 2010 Aug;10(8):951-8. doi: 10.1016/j.intimp.2010.05.008. Epub 2010 May 28.
- Results Chan, R.Y.P., & Chien, W.T. (2013). Concepts of body constitution, health and sub-health from traditional Chinese medicine perspective. World Journal of Translational Medicine, 2(3), 56-66. (doi:10.5528/wjtm.v2.i3.56).
- Results Chan RY, Chien WT. The effects of two Chinese herbal medicinal formulae vs. placebo controls for treatment of allergic rhinitis: a randomised controlled trial. Trials. 2014 Jul 2;15:261. doi: 10.1186/1745-6215-15-261.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cure-Allergic Rhinitis Syrup | Traditional medicine (herbal / TCM) | 20 ml | Oral |
| Comparator | Yu-ping-fung San | Traditional medicine (herbal / TCM) | 20 ml | Oral |