Comparison of Two Different Doses of Rabbit ATG-Fresenius With Cyclosporin in the Treatment of Acquired Aplastic Anaemia

Summary

Acquired Aplastic anemia is one of the most frequent reason of bone marrow failure in East (Pakistan). * The first treatment option is Allogenic Bone Marrow transplantation which is an expansive treatment option and also require a full matched HLA identical donor, hence hardly 25% of our affected patients get opportunity for BMT. * The second line treatment option caters a large chunk of patients (severe and non-severe AA) along with those who lack HLA identical donor. Previously many protocols had been used in past for ATG+CsA Treatment, this treatment protocol especially addresses the two different regimens of ATG to study its efficacy, durability and long-term effects. Following doses would be used: * CsA+ATG @ 10mg/kg for 3 days * CsA+ATG @ 10mg/kg for 5 days

Timeline

Start

2013-09

Primary completion

2017-12

Completion

2017-12

Drugs

Indications