drugset / Trial / NCT02034435
Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism
RandomizedCrossoverDouble-blindBasic science
Summary
Aim 1.Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system impairs glycemic control via effects on insulin sensitivity and insulin secretion. Aim 2. Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system impairs insulin secretion and insulin sensitivity via an mineralocorticoid-receptor dependent mechanism.
Timeline
- Start
- 2013-10
- Primary completion
- 2019-12
- Completion
- 2019-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amlodipine | Other / unclassified | 5 mg | — |
| Comparator | Epleronone | Unknown | 50 mg | — |