The Effect of Hydroxyethylstarch 6% 130/0.4 in a Balanced Electrolyte Solution (Volulyte®) Compared to Gelatine (Geloplasma®) on Microvascular Reactivity and Tissue Oxygen Saturation During Haemodilution Measured With Near-infrared Spectroscopy

NCT02034682 ↗

Completed 40 enrolled University Hospital, Ghent

RandomizedParallel-groupDouble-blindTreatment

Summary

The aim of this study is to compare 6% hydroxyethyl starch (HES) 130/0.4 in a balanced electrolyte solution (Volulyte®) with modified fluid gelatin (Geloplasma®) as the priming solution for the cardiopulmonary bypass (CPB) circuit. The microvascular reactivity and the effects on tissue (StO2) and cerebral (ScO2) oxygen saturation will be examined using near-infrared spectroscopy (NIRS).

Timeline

Start: 2014-01
Primary completion: 2014-08
Completion: 2015-04

Publications

Vandenbulcke L, Lapage KG, Vanderstraeten KV, De Somer FM, De Hert SG, Moerman AT. Microvascular reactivity monitored with near-infrared spectroscopy is impaired after induction of anaesthesia in cardiac surgery patients: An observational study. Eur J Anaesthesiol. 2017 Oct;34(10):688-694. doi: 10.1097/EJA.0000000000000684.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	hydroxyethyl starch	Other / unclassified	6 %	Other
Comparator	modified fluid gelatin	Other / unclassified	—	Other

Indications

No indication recorded.