drugset / Trial / NCT02050893
The Effect of Midazolam on Fluid Responsiveness in Septic Patients
RandomizedParallel-groupOpen-labelTreatment
Summary
Fluid resuscitation remains the foundation for septic treatment.The evaluation of fluid responsiveness has significance in volume resuscitation for septic shock patients. As the sedative which is commonly used in ICU, Midazolam is supposed to change fluid responsiveness for the pharmacological effect of venodilation. However, the hypothesis has not been certified clinically. In this research, the investigators aim to test the hypothesis that Midazolam can increase fluid responsiveness(using passive leg raising test) in septic shock patients.
Timeline
- Start
- 2012-05
- Primary completion
- 2013-04
- Completion
- 2013-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Midazolam | Small molecule | 0.02 mg/kg | — |
| Subject | Midazolam | Small molecule | 0.1 mg/kg | — |
| Subject | Propofol | Small molecule | 0.5 mg/kg | — |
| Subject | Propofol | Small molecule | 2 mg/kg | — |