Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN)

Summary

Predictive factors and biomarkers of response to antidepressants in major depressive disorder are scarce. Beta-arrestins are proteins which inhibit G Protein Coupled Receptors and desensitize serotonergic and dopaminergic receptors. The study hypothesis is that Beta-arrestins 1 and 2 are predictive factors and biomarkers of response to antidepressants in major depressive disorder. In a controlled prospective open naturalistic monocentric 3-month study, 60 patients with a major depressive disorder requiring a treatment with venlafaxine will be included and assessed before treatment, 1 month and 3 months post-treatment. 20 controlled healthy subjects matched for age and gender will also be assessed. The Beta-arrestin pathway will be assessed using genetic polymorphisms, Peripheral Blood Mononuclear Cell measures and functional pathway. Antidepressant response will be assessed using depression scales, olfaction and memory as surrogate markers of neurogenesis.

Timeline

Start

2014-02-18

Primary completion

2018-05

Completion

2018-05

Publications

• Results Colle R, El Asmar K, Verstuyft C, Lledo PM, Lazarini F, Chappell K, Deflesselle E, Ait Tayeb AEK, Falissard B, Duron E, Rotenberg S, Costemale-Lacoste JF, David DJ, Gressier F, Gardier AM, Hummel T, Becquemont L, Corruble E. The olfactory deficits of depressed patients are restored after remission with venlafaxine treatment. Psychol Med. 2022 Aug;52(11):2062-2070. doi: 10.1017/S0033291720003918. Epub 2020 Oct 22.
• Results Baudouin E, Corruble E, Gori P, Bloch I, Becquemont L, Duron E, Colle R. White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65. Braz J Psychiatry. 2025;47:e20243921. doi: 10.47626/1516-4446-2024-3921. Epub 2024 Dec 28.
• Results Mesdom P, Colle R, Becquemont L, Chappell K, David DJ, Mendez-David I, Corruble E, Verstuyft C. Tobacco use is associated with low peripheral beta-arrestin 1 levels in major depression: A preliminary report. Drug Alcohol Depend. 2022 Nov 1;240:109653. doi: 10.1016/j.drugalcdep.2022.109653. Epub 2022 Oct 2.
• Results Etienne J, Boutigny A, David DJ, Deflesselle E, Gressier F, Becquemont L, Corruble E, Colle R. Habenular volume changes after venlafaxine treatment in patients with major depression. Psychiatry Clin Neurosci. 2024 Aug;78(8):468-472. doi: 10.1111/pcn.13684. Epub 2024 Jun 12.
• Results Cussotto S, Colle R, Voican CS, Ciocan DM, Trainel N, Bottemanne H, Pelloux Y, David DJ, Cassard AM, Perlemuter G, Corruble E. The Gut Microbiota Is Altered in Antidepressant-Free Depressed Patients and Is Associated With Depression Severity. J Neurochem. 2025 Jul;169(7):e70173. doi: 10.1111/jnc.70173.

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Indications