Ranolazine and Microvascular Angina by PET in the Emergency Department

NCT02052011 ↗

Phase 4 Completed 31 enrolled Yale University Gilead Sciences · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine the effectiveness of Ranolazine for the treatment chest pain from disease of small vessels of the heart also known as 'microvascular angina'.

Timeline

Start: 2014-04
Primary completion: 2015-11
Completion: 2015-11

Outcome

Missed primary endpoint

paper there was no significant difference in the primary outcome as measured by mean change in CFR PMID 28081848 ↗

registry Mean Difference (Final Values) 0.27 (95% CI -0.08 to 0.62) NCT02052011 ↗

Publications

Safdar B, D'Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Ranolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled Trial. Clin Ther. 2017 Jan;39(1):55-63. doi: 10.1016/j.clinthera.2016.12.002. Epub 2017 Jan 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ranolazine	Small molecule	1000 mg	—