Drug-Drug Interaction Study Between CJ-12420 and Clarithromycin in Healthy Male Subjects

NCT02052336 ↗

Phase 1 Completed 24 enrolled HK inno.N Corporation

RandomizedCrossoverOpen-labelBasic science

Summary

Primary Objective: To assess the effect of the coadministration of multiple dose of CJ-12420 and clarithromycin on the pharmacokinetics (PK) of CJ-12420 or clarithromycin. Secondary Objective(s): To assess the safety of the coadministration of multiple dose of CJ-12420 and clarithromycin in healthy subjects

Timeline

Start: 2013-10
Primary completion: 2014-01
Completion: 2014-11

Publications

Oh M, Lee H, Kim S, Kim B, Song GS, Shin JG, Ghim JL. Evaluation of pharmacokinetic drug-drug interaction between tegoprazan and clarithromycin in healthy subjects. Transl Clin Pharmacol. 2023 Jun;31(2):114-123. doi: 10.12793/tcp.2023.31.e11. Epub 2023 Jun 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clarithromycin	Small molecule	500 mg	—
Subject	Tegoprazan	Other / unclassified	200 mg	—

Indications

No indication recorded.