Statin Therapy in Acute Influenza

Summary

Influenza (the 'flu') is a common virus infecting approximately 5-20% of the population in the United States and causing as many as 500,000 deaths worldwide each year. Currently, there are only a few treatments for influenza infection and none of these target inflammation that can be caused by the virus. This study will test whether the anti-inflammatory effects of statins, a class of drugs most often used to treat high cholesterol, will decrease the severity of illness in patients who are infected with influenza by testing markers of inflammation in the blood and recording resolution of influenza illness.

Timeline

Start

2013-10

Primary completion

2018-06-30

Completion

2018-06-30

Publications

• Chase M, Cocchi MN, Grossestreuer AV, Liu X, Vine J, Moskowitz AL, Donnino MW. Randomized Controlled Trial of Atorvastatin in Acute Influenza in the Emergency Department. West J Emerg Med. 2025 Apr 29;26(3):600-608. doi: 10.5811/westjem.33580.

Drugs

Indications