Impact of Oral Antibiotic Treatment on C. Difficile

Summary

The overall aim is to characterize and to compare the extent and quantity of C. difficile stool shedding, perianal colonization and environmental contamination in patients who received oral fidaxomicin, oral metronidazole, or oral vancomycin. This is a prospective, randomized, microbiologic and molecular, study of environmental contamination from patients with proven C. difficile associated diarrhea (CDAD).

Timeline

Start

2014-06-10

Primary completion

2017-06-27

Completion

2017-06-27

Publications

• Turner NA, Warren BG, Gergen-Teague MF, Addison RM, Addison B, Rutala WA, Weber DJ, Sexton DJ, Anderson DJ. Impact of Oral Metronidazole, Vancomycin, and Fidaxomicin on Host Shedding and Environmental Contamination With Clostridioides difficile. Clin Infect Dis. 2022 Mar 1;74(4):648-656. doi: 10.1093/cid/ciab473.

Drugs

Indications