Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3)

Summary

To determine the effect of 12 weeks of chronic PDEV inhibition with Tadalafil versus placebo on basal cardiorenal and humoral function and on the integrated cardiorenal and humoral response to acute sodium loading in subjects with preclinical Diastolic dysfunction (PDD) and renal (kidney) dysfunction

Timeline

Start

2014-03

Primary completion

2019-06

Completion

2019-12

Publications

• Vinnakota S, Adel FW, McKie PM, Scott CG, Chen HH. The Cardiorenal Effects of Chronic Phosphodiesterase-V Inhibition in Preclinical Diastolic Dysfunction (Stage B Heart Failure). J Card Fail. 2023 Oct;29(10):1461-1465. doi: 10.1016/j.cardfail.2023.05.019. Epub 2023 Jun 7.

Drugs

Indications