drugset / Trial / NCT02065843
Three Anxiolytic Drugs Used in Third Molar Surgery
Phase 2/3
Completed
30 enrolled
Federal University of Sergipe
University of Campinas, Brazil · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
This study was to compare the effectiveness of three drugs (Passiflora incarnata, Erythrina mulungum, Midazolam) in controlling anxiety in patients undergoing bilateral extraction of asymptomatic, impacted mandibular third molars.
Timeline
- Start
- 2014-03
- Primary completion
- 2014-04
- Completion
- 2014-09
Publications
- Background Balbani AP, Silva DH, Montovani JC. Patents of drugs extracted from Brazilian medicinal plants. Expert Opin Ther Pat. 2009 Apr;19(4):461-73. doi: 10.1517/13543770902824180.
- Background Flausino OA Jr, Pereira AM, da Silva Bolzani V, Nunes-de-Souza RL. Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety. Biol Pharm Bull. 2007 Feb;30(2):375-8. doi: 10.1248/bpb.30.375.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Midazolam | Small molecule | 15 mg | Oral |
| Comparator | Mulungu | Unknown | 500 mg | Oral |
| Comparator | Passiflora incarnata | Unknown | 100 mg | Oral |