drugset / Trial / NCT02071537
Chloroquine in Combination With Carboplatin/Gemcitabine in Advanced Solid Tumors
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this research study is to test the safety of chloroquine in combination with carboplatin and gemcitabine and see what effects (good and bad) it has on advanced solid tumors. Also, the research study will be increasing the dose of chloroquine to find the highest dose of chloroquine that can be given in combination with carboplatin and gemcitabine without causing severe side effects.
Timeline
- Start
- 2014-05-13
- Primary completion
- 2018-03-03
- Completion
- 2018-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Chloroquine | Small molecule | 50 mg | Oral |
| Subject | Chloroquine | Small molecule | 100 mg | Oral |
| Subject | Chloroquine | Small molecule | 150 mg | Oral |
| Subject | Chloroquine | Small molecule | 200 mg | Oral |
| Background | Carboplatin | Small molecule | — | — |
| Background | Gemcitabine | Small molecule | 1250 mg/m2 | — |