drugset / Trial / NCT02076451

Open-label Study of DS-8273a to Assess Its Safety and Tolerability, and Assess Its Pharmacokinetic and Pharmacodynamic Properties in Subjects With Advanced Solid Tumors or Lymphomas

NCT02076451

Phase 1 Completed 32 enrolled Daiichi Sankyo
Non-randomizedSingle-groupOpen-labelTreatment

Summary

This will be a Phase 1, open-label study of DS-8273a to assess its safety and tolerability, identify the Maximum Tolerated Dose and/or Maximum Administered Dose, and assess its properties in subjects with advanced solid tumors or lymphomas. Up to 5 US sites are planned for participation in Part 1 (Dose Escalation) and Part 2 (Dose Expansion) in subjects with solid tumors or lymphomas.

Timeline

Start
2014-02
Primary completion
2015-12
Completion
2015-12

Drugs

EvaluationDrugModalityDoseRoute
Subject DS-8273a Monoclonal antibody 2 mg/kg Intravenous
Subject DS-8273a Monoclonal antibody 8 mg/kg Intravenous
Subject DS-8273a Monoclonal antibody 16 mg/kg Intravenous
Subject DS-8273a Monoclonal antibody 24 mg/kg Intravenous

Indications