The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Healthy Humans. A Dose-response Study

Summary

The purpose of this study is to investigate the effect of different doses of sodium nitrite infusion in 12 healthy subjects. The effects on renal handling of nitrite, nitrate, sodium and water, plasma concentrations of vasoactive hormones, peripheral (brachial) and central blood pressure will be evaluated. Hypothesis Sodium nitrite infusion 1. increases urinary sodium excretion and renal filtration rate 2. lowers blood pressure, central as well as peripheral 3. affects vasoactive hormones 4. it is possible to establish a dose that affects the renal function with only minor effect on the blood pressure.

Timeline

Start

2013-09

Primary completion

2014-06

Completion

2014-06

Drugs

Indications

No indication recorded.