drugset / Trial / NCT02085317
Microcirculatory Impairment in Patients With Leprosy
Non-randomizedParallel-groupOpen-labelBasic science
Summary
In this study the investigators have aimed to evaluate morphology and reactivity of cutaneous microcirculation in patients with lepromatous leprosy. Ten patients, without any other comorbidity were compared to ten controls without leprosy or any other comorbidity, using the Cytoscan® \[orthogonal polarization spectral (OPS) imaging\], Fourier analysis of laser Doppler signal to evaluate vasomotion (rhythmic spontaneous oscillation of arteriolar diameter) and laser Doppler flowmetry associated to iontophoresis of vasoactive substances (acetylcholine and sodium nitroprusside).
Timeline
- Start
- 2006-03
- Primary completion
- 2009-11
- Completion
- 2010-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetylcholine | Small molecule | 0.1 ml | Other |
| Subject | Sodium Nitroprusside | Unknown | 0.1 ml | Other |