Effects of Atorvastatin on Human Semen and Gonadal Hormones

NCT02094313 ↗

Phase 1 Completed 17 enrolled University Hospital, Clermont-Ferrand EA 975, Laboratoire de BDR · collab Laboratoire d'Hormonologie - Biochimie · collab Service d'Endocrinologie, Diabète et Maladies Métaboliques · collab Service de Biologie de la Reproduction : AMP-CECOS · collab

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Recently, concerns about the effect of atorvastatin intake on men fertility have been raised. However, this statin has never been investigated regarding its influence on male fertility, notably sperm quality. The aim of this pilot study is to evaluate the efficacy and the safety of a decrease of cholesterol blood levels, induced by taking atorvastatin, on sperm quality of normocholesterolaemic and healthy men without confounding factors.

Timeline

Start: 2008-01
Primary completion: 2014-01
Completion: 2014-01

Publications

Pons-Rejraji H, Brugnon F, Sion B, Maqdasy S, Gouby G, Pereira B, Marceau G, Gremeau AS, Drevet J, Grizard G, Janny L, Tauveron I. Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial. Reprod Biol Endocrinol. 2014 Jul 12;12:65. doi: 10.1186/1477-7827-12-65.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atorvastatin	Small molecule	10 mg	Oral

Indications

No indication recorded.