Ketamine for Depression and Suicide Risk

Summary

The purpose of this research study was to find out if the medication known as ketamine could help the symptoms of depression. This drug is approved by the U.S. Food and Drug Administration (FDA) as an anesthetic agent; however, it is not approved for use in depression treatment. The FDA allowed the use of this drug in this research study.

Timeline

Start

2014-09

Primary completion

2016-07

Completion

2016-08

Outcome

Met primary endpoint

registry analysis (superiority test); Entire Cohort; p <0.01; t-test, 2 sided NCT02094898 ↗

Publications

• Results Vande Voort JL, Morgan RJ, Kung S, Rasmussen KG, Rico J, Palmer BA, Schak KM, Tye SJ, Ritter MJ, Frye MA, Bobo WV. Continuation phase intravenous ketamine in adults with treatment-resistant depression. J Affect Disord. 2016 Dec;206:300-304. doi: 10.1016/j.jad.2016.09.008. Epub 2016 Sep 12.

Drugs

Indications