The Effect of Short-term Atorvastatin Treatment on Immune Responses to Pneumovax 23

NCT02097589 ↗

Phase 1 Completed 33 enrolled University of Florida

RandomizedParallel-groupDouble-blindHealth-services research

Summary

The purpose of this research study is to: Improve the effectiveness of vaccinations by identifying the effect of cholesterol medication, statins, on immune responses.

Timeline

Start: 2014-06
Primary completion: 2014-09
Completion: 2014-09

Outcome

Met primary endpoint

paper significant increase in fold change of total anti-pneumococcal antibody titer in the atorvastatin group compared to the placebo group (2-way ANOVA, p = .0177). PMID 30686636 ↗

Publications

Wildes TJ, Grippin A, Fasanya H, Dyson KA, Brantly M. Effect of atorvastatin on humoral immune response to 23-valent pneumococcal polysaccharide vaccination in healthy volunteers: The StatVax randomized clinical trial. Vaccine. 2019 Feb 28;37(10):1313-1324. doi: 10.1016/j.vaccine.2019.01.023. Epub 2019 Jan 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atorvastatin	Small molecule	40 mg	Oral
Background	Pneumovax 23	Vaccine	—	Intramuscular

Indications

No indication recorded.