Efficacy of Intrathecal Oxytocin in Patients With Neuropathic Pain

Phase 2 Terminated 8 enrolled Wake Forest University Health Sciences

RandomizedCrossoverTriple-blindBasic science

Summary

The purpose of the study is to determine the effect of oxytocin given into the spinal fluid on pain and areas and intensity of hyperalgesia and allodynia in patients with chronic neuropathic pain.

Timeline

Start: 2014-06-19
Primary completion: 2022-10-10
Completion: 2022-10-10

Outcome

Met primary endpoint

Stopped (Enrollment): “Cessation of funding period prior to completion, due to slow recruitment during the pandemic”

paper modeled pain intensity decreased more after oxytocin than placebo to 1.61 ± 0.87 and 2.49 ± 0.87, respectively (P = .003). PMID 37084261 ↗

Publications

Eisenach JC, Curry RS, Houle TT. Preliminary results from a randomized, controlled, cross-over trial of intrathecal oxytocin for neuropathic pain. Pain Med. 2023 Sep 1;24(9):1058-1065. doi: 10.1093/pm/pnad051.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oxytocin	Peptide	100 ug	Intrathecal