Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye

Phase 2 Completed 40 enrolled Dompé Farmaceutici S.p.A Cross Research S.A. · collab

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The primary objective of this study was to assess the efficacy and safety of different doses of rhNGF when administered as eye drops to patients with dry eye.

Timeline

Start: 2014-01-20
Primary completion: 2015-01
Completion: 2015-01

Publications

Sacchetti M, Lambiase A, Schmidl D, Schmetterer L, Ferrari M, Mantelli F, Allegretti M, Garhoefer G. Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study. Br J Ophthalmol. 2020 Jan;104(1):127-135. doi: 10.1136/bjophthalmol-2018-312470. Epub 2019 Apr 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	rhNGF	Protein / enzyme biologic	4 ug/ml	Other
Subject	rhNGF	Protein / enzyme biologic	20 ug/ml	Other

Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye

Summary

Timeline

Publications

Drugs

Indications