Drug Interaction Study Between Bosutinib And Dabigatran

Phase 1 Completed 27 enrolled Pfizer

RandomizedCrossoverOpen-labelBasic science

Summary

The study evaluates the effect of a single oral dose of bosutinib on the single dose pharmacokinetics of dabigatran, a p-glycoprotein substrate, in healthy subjects.

Timeline

Start: 2014-05
Primary completion: 2014-06
Completion: 2014-06

Publications

Hsyu PH, Pignataro DS, Matschke K. Effect of bosutinib on the absorption of dabigatran etexilate mesylate, a P-glycoprotein substrate, in healthy subjects. Eur J Clin Pharmacol. 2017 Jan;73(1):57-63. doi: 10.1007/s00228-016-2115-0. Epub 2016 Oct 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bosutinib	Small molecule	500 mg	Oral
Subject	Dabigatran	Unknown	150 mg	Oral

Indications

No indication recorded.