drugset

drugset / Trial / NCT02104505

Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled LPS

NCT02104505 ↗

Phase 1/2 Completed 23 enrolled University of North Carolina, Chapel Hill National Institute of Environmental Health Sciences (NIEHS) · collab Purdue University · collab

RandomizedCrossoverDouble-blindTreatment

Summary

To test the hypothesis that gamma tocopherol (vitamin E) supplement inhibits endotoxin induced airways inflammation in allergic asthmatics

Timeline

Start: 2015-11
Primary completion: 2016-09
Completion: 2017-08

Publications

Burbank AJ, Duran CG, Pan Y, Burns P, Jones S, Jiang Q, Yang C, Jenkins S, Wells H, Alexis N, Kesimer M, Bennett WD, Zhou H, Peden DB, Hernandez ML. Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma. J Allergy Clin Immunol. 2018 Apr;141(4):1231-1238.e1. doi: 10.1016/j.jaci.2017.06.029. Epub 2017 Jul 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Gamma Tocopherol	Unknown	700 mg	—

Indications