Study of the Symptomatic Effects of Nocturnal Sodium Oxybate in Parkinson's Disease

Summary

Sleep wake disturbance is a common problem in Parkinson's disease patients and so far the therapeutic possibilities for symptomatic relief are limited. Small, open-label studies indicate that the use of Xyrem (gamma-hydroxybutyrate) might be of benefit in this situation. This study is intended to show a beneficial effect of the study medication in a randomized cross-over trial, that fulfills strict scientific criteria.

Timeline

Start

2014-04

Primary completion

2016-04

Completion

2016-08

Publications

• Buchele F, Hackius M, Schreglmann SR, Omlor W, Werth E, Maric A, Imbach LL, Hagele-Link S, Waldvogel D, Baumann CR. Sodium Oxybate for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 Jan 1;75(1):114-118. doi: 10.1001/jamaneurol.2017.3171.

Drugs

Indications