Effects of Helicobacter Pylori Infection Eradication in Patients With Parkinson's Disease

Summary

A higher prevalence of Helicobacter pylori infection rate has been demonstrated among PD patients compared to controls. As H. pylori infection is known to interfere with levodopa absorption, we embarked on this is a study to understand the effects of Helicobacter pylori infection eradication among a selected Malaysian population with Parkinsons disease, in relation to levodopa effectiveness and motor improvements. The study hypotheses are: 1. H. pylori eradication improves L-dopa 'onset' time and prolongs the L-dopa 'on-time' duration. 2. PD patients with H. pylori infection show clinical improvement in motor disability and quality of life after eradication therapy of H. pylori, assessed using UPDRS-III / PDQ39 questionnaires.

Timeline

Start

2012-12

Primary completion

2013-03

Completion

2013-04

Publications

• Hashim H, Azmin S, Razlan H, Yahya NW, Tan HJ, Manaf MR, Ibrahim NM. Eradication of Helicobacter pylori infection improves levodopa action, clinical symptoms and quality of life in patients with Parkinson's disease. PLoS One. 2014 Nov 20;9(11):e112330. doi: 10.1371/journal.pone.0112330. eCollection 2014.

Drugs

Indications

No indication recorded.