Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines

Phase 4 Unknown 100 enrolled Helsinki University Central Hospital

Non-randomizedParallel-groupOpen-labelPrevention

Summary

In a recent controlled study, the investigators explored cross-reactive immune responses against different Salmonella spp. in healthy volunteers immunized with either the oral (Vivotif® ) or parenteral (Typherix®) typhoid vaccines (ISRCTN68125331). In the present study immune responses will be studied in a group receiving both of these vaccines and in the previously immunized volunteers after booster immunization (same groups receive same vaccines 2-4 years after primary immunization).

Timeline

Start: 2013-10
Primary completion: 2019-12
Completion: 2019-12

Publications

Pakkanen SH, Kantele JM, Savolainen LE, Rombo L, Kantele A. Specific and cross-reactive immune response to oral Salmonella Typhi Ty21a and parenteral Vi capsular polysaccharide typhoid vaccines administered concomitantly. Vaccine. 2015 Jan 9;33(3):451-8. doi: 10.1016/j.vaccine.2014.11.030. Epub 2014 Nov 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Typhoid Vi vaccine	Vaccine	—	Intramuscular
Subject	Vivotif	Vaccine	—	Oral

Indications

No indication recorded.