Identifocation the B Cell Subsets Responsible for Anti-pneumococcal Response

Summary

The purpose of this study is to determine which B lymphocytes subsets are responsible for the production of IgM, IgG2 and IgA anti-pneumococcal capsular polysaccharides after vaccination with a 23-valent pneumococcal polysaccharide vaccine.

Timeline

Start

2014-11-18

Primary completion

2016-04

Completion

2016-04-05

Publications

• Results Weller S, Sterlin D, Fadeev T, Coignard E, Verge de Los Aires A, Goetz C, Fritzen R, Bahuaud M, Batteux F, Gorochov G, Weill JC, Reynaud CA. T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens. Sci Immunol. 2023 Jan 27;8(79):eade1413. doi: 10.1126/sciimmunol.ade1413. Epub 2023 Jan 27.

Drugs

Indications