drugset / Trial / NCT02126969
A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN
RandomizedParallel-groupSingle-blindTreatment
Summary
The primary hypothesis of this study is that hyper-radiosensitivity (HRS) seen at extremely low doses of radiation can be exploited to enhance the effect of chemotherapy, and that this effect differs from the cellular effect of higher, standard fractions of radiation used in traditional radiation treatment paradigms.
Timeline
- Start
- 2014-10
- Primary completion
- 2018-03
- Completion
- 2021-06-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Carboplatin | Small molecule | 6 unknown | — |
| Comparator | Docetaxel | Small molecule | 75 mg/m2 | — |