Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2)

Phase 2 Completed 69 enrolled The University of Texas Health Science Center at San Antonio American Diabetes Association · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to determine whether microbiome modulation and an experimental reduction in plasma LPS concentration improve inflammation and insulin action in insulin resistant (obese and T2DM) subjects.

Timeline

Start: 2014-04-10
Primary completion: 2018-09
Completion: 2018-09-10

Publications

Baeuerle E, Semwal MK, Nie J, Zhang N, Liang H, Ganapathy V, Sathavarodom N, Fernandez R, Wang CP, Espinoza S, Dong Q, Gao X, Yang Z, Kostic A, Musi N. Effect of Sevelamer and B. longum on Insulin Sensitivity in Participants With Obesity: A Randomized Clinical Trial. Obesity (Silver Spring). 2026 Jul;34(7):1382-1394. doi: 10.1002/oby.70224. Epub 2026 May 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bifidobacterium longum R0175	Unknown	1 g	—
Comparator	Oligofructose	Unknown	5 g	—
Comparator	Sevelamer	Other / unclassified	1.6 g	—

Indications

No indication recorded.