A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Repaglinide and Caffeine

Phase 1 Completed 24 enrolled Astellas Pharma Global Development, Inc. Basilea Pharmaceutica International Ltd · collab

NaSingle-groupOpen-labelBasic science

Summary

The purpose of this study is to assess the effect of multiple doses of isavuconazole on the pharmacokinetics of Repaglinide and possible metabolites after single dose administration. In addition, this study will assess the effect of multiple doses of isavuconazole on the pharmacokinetics of caffeine and possible metabolites after single dose administration. Safety and tolerability of isavuconazole alone and in combination with Repaglinide or in combination with caffeine will be assessed.

Timeline

Start: 2014-01
Primary completion: 2014-02
Completion: 2014-02

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Caffeine	Small molecule	—	Oral
Subject	Isavuconazole	Small molecule	—	Oral
Subject	Repaglinide	Small molecule	—	Oral

Indications

No indication recorded.